The effect of dextran sulphate injections on serum lipoproteins.

Studies of the effect of heparin injections on the serum lipoproteins of man and animals are in progress in several laboratories. Gofman and his collaborators have shown that heparin injection results in the larger lipoprotein complexes being converted to smaller ones as shown by the changes in ultra-centrifugal flotation patterns; see, for instance, Graham, Lyon, Gofman, Jones, Yankley, Simonton, and White (1951). Such changes are believed to be due to the liberation of a lipolytic enzyme in response to heparin injection (Shore, Nicols, and Freeman, 1953). Incubation of plasma containing this enzyme with lipaemic plasma causes a marked reduction in turbidity, and it seems possible that the lipolytic enzyme is